iBiology Techniques
iBiology Techniqueshttps://www.ibiology.org/bioengineering/biological-circuits/
In his iBiology talk, Dr. Timothy Lu describes how biological circuits, using principles from engineering, can be used as digital (all or none) or analog (continuous spectrum) sensors, and can be programmed in a cell to ‘remember’ an input and pass this memory to the cell’s offspring after it divides. Dr. Lu gives several examples of biological circuits that his lab created that can allow a cell to sense the extracellular environment and give a readable output that can be maintained through subsequent cell divisions. In the future, these types of circuits can be developed as non-invasive diagnostics or therapeutics in humans. Dr. Lu ends his talk by discussing the open challenges facing this area of synthetic biology.
Speaker Biography:
Timothy Lu is an Associate Professor of Biological Engineering and Electrical Engineering and Computer Science at MIT. He is also affiliated with the Broad Institute of MIT and Harvard. Dr. Lu received his undergraduate and M.Eng. degrees from MIT in Electrical Engineering and Computer Science. He then obtained an M.D. from Harvard Medical School and a Ph.D. from the Harvard-MIT Health Sciences and Technology Medical Engineering and Medical Physics Program. His work in the Synthetic Biology Group focuses on the utilization of engineered biological circuits and cellular sensors to tackle infectious diseases and amyloid-associated conditions, and make advancements in diagnostics, therapeutics, and biotechnology. Lu has been awarded many prizes, including the Lemelson-MIT Student Prize, Grand Prize in the National Inventor Hall of Fame’s Collegiate Inventors Competition, and the Leon Redneck Memorial Prize. He was also listed as one of TR35 Top 35 Innovators Under 35 (MIT Technology Review), as a Kavli Fellow by the National Academy of Sciences, and a Siebel Scholar.
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18 Comments
@josephwang9249
02/19/2025 - 5:34 PMTimestamps (to the best of my ability) (WIP)
0:00 Definition + Community
1:23 Innovations in DNA editing
2:27 Differences between biology and engineering
4:21 Biological circuits
6:14 Types of synthetic biology
7:15 Biological sensors
9:39 Digital and Analog Computation in Biology
12:46 Biological Digital Gate
13:41 Recombinases
14:57 Recombinase Switch Example
15:58 Higher Order Digital Logic Gates
17:48 Digital AND gate example
20:04 ALL the Biodigilogical Gates
20:24 Biological Memory/Inheritance of Gates
22:19 Platforms for computing information
22:37 Bioanalogical Computation
24:07 Description of Positive and Negative Logarithm Gene Circuit
27:27 Bioanalogical subtraction
28:05 Bioanalogical sensor
29:46 SCRIBE and Analogical measurements
33:43 Recombineering with Intracellulary Expressed ssDNAs (rework this later)
36:24 Use of Induction to Measure Temporarl Information
37:52 Potential Applications and Examples
40:19 Challenges in Synthetic Biology
@SuperElwira
02/19/2025 - 5:34 PMI am sceptic-look Thaidomid genetic med, look at Prozac, benzodiasepines side effects. Mother cells failed. Still bio farming, natural diet, sport, art, meditation, joga, acupunture, herbal healing, permaculture, biodiversity, ayurweda is the the best. I beg scientists to know this metods. Permaculture ecosystem biodiversity, natural herb, music healing. Please talk with bio farmers. Learn from them, help them rescue planet- neutralise toxins and waste in trash industry, producing recycle natural materials, clean water and air by producing natural membranes, filters, bacteria fermentation and acids, replacing chemical conservants, 3D food printers-liofilisates, dry herbs, ferment bacteria, maybe vitamines. Dont go into medicine. Replace pesticides. Please. Natural architecture materials-this you can bio design. Natural homes. We need more natural and ethical medicine because it has better results. I was not believe but it is truth. Life organisms is not toys-this is living, intelligent materials-they react, behave, feel. Science must understand this. People drop medicines and get heal with natural diet, sport, changing habits. We need only remove sugar and chemicals from food, environmant, heal addictions, aggression-thats all. Change finance, work, education, social system. Turn towns green with solar and vertical vegetable gardens. Toxic ambition and competition leads science and business. GMO only in labs or house design. We cant allow gmo to natural environmant-wild nature dies. GMO corn to feed animals- they get sick, need eat grass-vit K, we have stroke, heart attacks because animals font eat natural grass, don't see Sun, live in stress and dirt-we throw tones of food, we must design global production. HMO plants are less vitamines, taste, they need pesticides, they are living one season-seeds are useless. Please check farming and soul recovery programs with mushrooms, bacterias. Pesticides kill bees-they was precisely designed-structural analogs, Nobel prize and failed. Killing naturę, mutate kids living near by fields. Biodiversity fields font nerd pesticides. Feromone cathes for bugs, animals on fields- ducs, wild birds eat snales and worms. Its one system. Science and hunters, chemicals ruin this
@HumanRights-s1o
02/19/2025 - 5:34 PMexperiments and trafficking for developing Nanotechnology and Synthetic biology. The involved scientist have the same mind set like Dr Joseph Mengele had. Many NS scientist moved after worls war II by Operation Paperclip and until today continue their terrible work against humanity!
@thehumanconvergence
02/19/2025 - 5:34 PMGreat stuff, will be featuring you in our next episode!
@marikatarasashvili9253
02/19/2025 - 5:34 PMWow brilliant! Thank you very much!
@abangkisp
02/19/2025 - 5:34 PMI've been trying to learn about this field, my background is from software engineering. And this is the best video I've found so far. Even though it's from 6 years ago 😊
All the hurdle mentioned in the video is very true, but I think it's only a part why we don't have exponential growth in the field. The other part is that this is a "Mainframe vs PC" problem. One of the things that made software engineering expand so quickly is the introduction of PC. Currently SynBio is still in the Mainframe stage, where only a few could have access to it.
Of course is not wise to give everyone free access without control. Who knows what kind of random things could happened that create a mutation that could jeopardize the environment. So the other thing we need is "the internet" for SynBio. Somewhere people could do experiment in a safe way and show case it to other people, somethink akin to the internet in the dial up era. And maybe all of that creation could live in a controlled world. And interact naturally. It would be interesting to the things that could come up from a full humanity effort.
@pauljackways1473
02/19/2025 - 5:34 PMdisliking for not havig New Zealand on your map at the start
@cindymagnuson2453
02/19/2025 - 5:34 PM…remember what happened the last time abominations, instead of letting nature decide, ended up bringing about
@PROFjavi
02/19/2025 - 5:34 PMthis was by far the most densely packed review of syn bio ive found yet! would love to hear how things have now progressed or your recomendations on other fantastic talks7reviews
@mau345
02/19/2025 - 5:34 PMawesome awesome vid.
@imrematajz1624
02/19/2025 - 5:34 PMPossible avenue how to accelerate the critical process of cracking the RNA code of biological agents such as the Coronavirus CoVi2 2019 and leverage aggregate knowledge by using analogies from standard electric circuit analysis and computer programming with a healthy dose of system thinking and applying the scientific process.
@rickswancott1
02/19/2025 - 5:34 PMAn excellent resource for students looking for iGEM projects. Thanks.
@joesmith9330
02/19/2025 - 5:34 PMI WOULD USE THIS TO WRITE CODED MESSAGES IN AN AVIRULENT BACTERIA EAT IT THEN CROSS THE BORDER OF A COUNTRY THEN DECODE IT WITH A DNA READER
@GovernerOfBurningHam
02/19/2025 - 5:34 PMAbsolutely brilliant video. Helps me a lot with my QGEM proposal.
@superoxidedismutase5757
02/19/2025 - 5:34 PMcan't believe this channel only has 11k subs
@zs6564
02/19/2025 - 5:34 PM…lame
@tollerest
02/19/2025 - 5:34 PMso were not close to building organic battleships yet? All joking aside I'm an Electrical Engineer looking for a new discipline, Very Inspiring.
@joseinTokyo
02/19/2025 - 5:34 PMgenius